台灣大學漁業科學研究所

研究重點:
一、發育生物學
 二、發育基因體學
 三、海洋生物學

我的研究興趣在於瞭解頭索動物文昌魚的胚胎發育機制。文昌魚屬於脊索動物中的一個亞門，雖然它是無脊椎動物，但一般利用它作為一種模式生物來探討脊椎動物祖先可能具有的特徵。文昌魚與脊椎動物都具備脊索動物的基本特徵，例如：背神經管、脊索、肌節、以及鰓裂。然而脊椎動物進一步演化出文昌魚所沒有的特徵，包括：特化的頭部結構與前腦、具有遷移性的神經脊細胞群、以及經由外胚層增厚所產生的周圍感覺神經組織。我希望經由對文昌魚胚胎發育機制的研究來了解脊索動物發育的共同基礎機制；同時由於文昌魚在類緣關係上的特殊地位，文昌魚與脊椎動物的比較研究將可以提供重要的資訊來讓我們瞭解脊椎動物體制特徵發育的起源。

本實驗室初步研究重點之一為探討神經脊 (Neural crest) 的起源。在脊椎動物胚胎發育過程中，神經脊細胞是從神經板的邊緣產生。這些細胞會由表皮性的外胚層細胞轉變成一群具遷移性的細胞，並且在到達它們的遷移終點後分化成許多種不同的細胞，包括：頭部顏面骨骼、大部分的周圍神經細系統、以及皮膚的色素細胞等等。許多脊椎動物頭部特有的複雜感覺器官都包含了神經脊細胞所分化出來的構造，因此神經脊被認為是早期脊椎動物演化的重要特點之一。我們將比較文昌魚與脊椎動物胚胎神經板發育過程中的基因表現與調控，進而去瞭解發育基因網路的改變與神經脊起源的關係。

近年重要著作 (2017- ):

Yong LW, Lu TM, Tung CH, Chiou RJ, Li KL, & Yu JK* (2021) Somite compartments in amphioxus & its implications on the evolution of the vertebrate skeletal tissues. Front Cell Dev Biol, 9:607057.

Lin CY, Yu JK*, & Su YH* (2021) Evidence for BMP-mediated specification of primordial germ cells in an indirect-developing hemichordate. Evol & Dev, 23:28-45.

Lin CY, Lu MYJ, Yue JX, Li KL. Le Pétillon Y, Yong LW, Chen YH, Tsai FU, Lyu YF, Chen CY, Hwang SPL, Su YH*, & Yu JK* (2020) Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling. PLOS Genetics, 16:e1009294.

Simakov O*, Marletaz F, Yue JX, O'Connell B, Jenkins J, Br&t A, Calef R, Tung CH, Huang TK, Schmutz J, Satoh N, Yu JK, Putnam NH, Green RE, & Rokhsar DS* (2020) Deeply conserved synteny resolves early events in vertebrate evolution. Nat Ecol Evol, 4:820-830.

Su YH*, Chen YC, Ting HC, Fan TP, Lin CY, Wang KT, & Yu JK* (2019) BMP controls dorsoventral & neural patterning in indirect-developing hemichordates providing insight into a possible origin of chordates. Proc Natl Acad Sci USA, 116(26):12925-12932.

Kawaguchi M, Sugiyama K, Matsubara K, Lin CY, Kuraku S, Hashimoto S, Suwa Y, Yong LW, Takino K, Higashida S, Kawamura D, Yu JK & Seki Y*(2019) Co-option of the PRDM14–CBFA2T complex from motor neurons to pluripotent cells during vertebrate evolution. Development, 146: dev168633.

Marletaz F, Firbas PN, Maeso I*, Tena JJ, Bogdanovic O, Perry M, Wyatt CDR, de la Calle-Mustienes E, Bertr& S, Burguera D, Acemel RD, van Heeringen SJ, Naranjo S, Herrera-Ubeda C, Skvortsova K, Jimenez-Gancedo S, Aldea D, Marquez Y, Buono L, Kozmikova I, Permanyer J, Louis A, Albuixech-Crespo B, Le Petillon Y, Leon A, Subirana L, Balwierz PJ, Duckett PE, Farahani E, Aury JM, Mangenot S, Wincker P, Albalat R, Benito-Gutierrez E, Canestro C, Castro F, D'Aniello S, Ferrier DEK, Huang S, Laudet V, Marais GAB, Pontarotti P, Schubert M, Seitz H, Somorjai I, Takahashi T, Mirabeau O, Xu A, Yu JK, Carninci P, Martinez-Morales JR, Crollius HR, Kozmik Z, Weirauch MT, Garcia-Fern&ez J, Lister R, Lenhard B, Holland PWH, Escriva H*, Gomez-Skarmeta JL*, & Irimia M* (2018) Amphioxus functional genomics & the origins of vertebrate gene regulation. Nature. 564:64-70.

Nakashima K*, Kimura S, Ogawa Y, Watanabe S, Soma S, Kaneko T, Yamada L, Sawada H, Tung CH, Lu TM, Yu JK, Villar-Briones A, Kikuchi S, & Satoh N (2018) Chitin-based barrier immunity & its loss predated mucus-colonization by indigenous gut microbiota. Nat Commun, 9(1):3402.

Zieger E, Garbarino G, Robert NSM, Yu JK, Croce JC, C&iani S, & Schubert M* (2018) Retinoic acid signaling & neurogenic niche regulation in the developing peripheral nervous system of the cephalochordate amphioxus. Cellular & Molecular Life Sciences, 75(13):2407-2429.

Hu H, Uesaka M, Guo S, Shimai K, Lu TM, Li F, Fujimoto S, Ishikawa M, Liu S, Sasagawa Y, Zhang G, Kuratani S, Yu JK, Kusakabe TG, Khaitovich P, Irie N*, & the EXP&E Consortium (2017) Constrained vertebrate evolution by pleiotropic genes. Nat Ecol Evol, 1(11):1722-1730.

Yong LW, Bertr& S, Yu JK, Escriva H, & Holland ND* (2017) Conservation of BMP2/4 expression patterns within the Glade Branchiostoma (amphioxus): Resolving interspecific discrepancies. Gene Expression Patterns, 25-26:71-75.

Su YH* & Yu JK (2017) EvoDevo: Changes in developmental controls underlying the evolution of animal body plans. Developmental Biology, 427(2):177-178. SI.

Kozmikova I* & Yu JK* (2017) Dorsal-ventral patterning in amphioxus: current underst&ing, unresolved issues, & future directions. International Journal of Developmental Biology, 61(10-12):601-610.